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The U.S. Food and Drug Administration has approved using Contrave (naltrexone hydrochloride and bupropion hydrochloride extended-release tablets) to help manage chronic obesity in grown-ups with a body mass index (BMI) of greater than 27, so long as they also experience weight-related health concerns such as Tupe2 diabestes, high cholesterol levels and/or hypertension (blood pressure).Contrave can be a combination of two FDA-approved drugs, naltrexone and bupropion, within an extended-release formulation. Naltrexone qualifies to treat alcohol and opioid dependence. Bupropion is eligible to treat depression and seasonal affective disorder so when an aid to stopping smoking treatment.'Obesity may be a major public health concern,' said Jean-Marc Guettier, M.D., director from the Division of Metabolism and Endocrinology Products in FDA's Center for Drug Evaluation and Research. 'When used as directed in combination having a healthy lifestyle which includes a reduced-calorie exercise and dieting, Contrave provides another treatment option for chronic weight reduction for people who are obese or are overweight and have at least one weight-related health condition.'The drug's effectiveness was evaluated in multiple many studies that included approximately 4,500 obese and overweight patients with and without significant weight-related conditions treated for one year. All patients received lifestyle modification that contains a reduced- calorie diet and regular physical exercise. Results from a medical trial that enrolled patients without diabetes showed that patients had a typical weight loss of four years old.1% in contrast to participants who were given placebos) within a 12- month period, while another study involving patients with diabetes type 2 symptoms had a normal weight loss of 2% over treatment with placebo at one year.

Using two separate drugs to shed weight can be very effective you'll find combinations as you're watching FDA now awaiting approval. When dealing with weight-loss and the individuals who go through it you should err to the side of caution and allow the FDA do its job and demand some research be done so the public understands the side effects and risks of the medications before we bring them. Keep in mind that drug companies come in business to generate money and that they would say everything to keep people on their medications.

Researchers discovered that participants taking this drug to get a year, lost excess weight within four weeks and have kept the load off throughout the 56 weeks of the study. Contrave is a combination from the drugs naltrexone and bupropion, which generally seems to reflect a whole new trend of weight-loss drugs which might be made up of more than one active ingredient, which can make them more efficient and safer.

Combo-pilling may be the newest fad or better yet the newest ahead under scrutiny and so it is just more publicly known lately, comb-pilling for weight loss has been around since the eighties. The biggest reason that by using a combination of pills is starting to become popular is the fact that by right now there are no long term prescription weight loss supplements that have been licensed by the FDA apart from orlistat. The truly disturbing part is doctors are prescribing these combinations of medications however some of the combinations happen to be rejected or have yet to be approved by the FDA.

Seizures really are a side effect with Contrave and shouldn't be taken in those with seizure disorders. The drug also can raise blood pressure level and heartbeat, and really should not be used in people who have a history of heart attack or stroke in the earlier six months. Blood pressure and pulse should also be measured before beginning the drug and throughout therapy using the drug.

The FDA also warned that Contrave can raise blood pressure and heart rate and must stop used in patients with uncontrolled high hypertension, in addition to by you aren't heart-related and cerebrovascular (circulation dysfunction impacting the brain) disease. Patients having a history of cardiac arrest or stroke in the previous six months, life-threatening arrhythmias, or congestive heart failure were excluded from your clinical trials. Those taking Contrave needs to have their heart-rate and pulse monitored regularly. In addition, since compound includes bupropion, Contrave comes having a boxed warning to alert medical researchers and patients to the increased probability of suicidal thoughts and behaviors connected with antidepressant drugs. The warning also notes that serious neuropsychiatric events have been reported in patients taking bupropion for stop smoking.

"There were no warning signs of depression or suicidal thoughts in trial participants," said Fujioka.